In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is still the poorest prognostic tumor of the digestive system. We investigated the antitumoral role of orexin-A and almorexant in PDAC. We analyzed the orexin receptor type 1 (OX1R) expression by immunohistochemistry in human normal pancreas, PDAC and its prec...

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Vydáno v:Oncotarget
Hlavní autoři: Dayot, Stéphanie, Speisky, Daniela, Couvelard, Anne, Bourgoin, Pierre, Gratio, Valérie, Cros, Jérôme, Rebours, Vinciane, Sauvanet, Alain, Bedossa, Pierre, Paradis, Valérie, Ruszniewski, Philippe, Couvineau, Alain, Voisin, Thierry
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805528/
https://ncbi.nlm.nih.gov/pubmed/29467942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24084
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