The Dual Orexin/Hypocretin Receptor Antagonist, Almorexant, in the Ventral Tegmental Area Attenuates Ethanol Self-Administration

Recent studies have implicated the hypocretin/orexinergic system in reward-seeking behavior. Almorexant, a dual orexin/hypocretin R(1) and R(2) receptor antagonist, has proven effective in preclinical studies in promoting sleep in animal models and was in Phase III clinical trials for sleep disorder...

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Main Authors: Srinivasan, Subhashini, Simms, Jeffrey A., Nielsen, Carsten K., Lieske, Steven P., Bito-Onon, Jade J., Yi, Henry, Hopf, Frederic Woodward, Bonci, Antonello, Bartlett, Selena E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448615/
https://ncbi.nlm.nih.gov/pubmed/23028593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044726
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