Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells

Glioblastoma (GBM) cells are characterized by high phagocytosis, lipogenesis, exocytosis activities, low autophagy capacity and high lysosomal demand are necessary for survival and invasion. The lysosome stands at the cross roads of lipid biosynthesis, transporting, sorting between exogenous and end...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Hsu, Sanford P.C., Kuo, John S., Chiang, Hsin-Chien, Wang, Hsin-Ell, Wang, Yu-Shan, Huang, Cheng-Chung, Huang, Yi-Chun, Chi, Mau-Shin, Mehta, Minesh P., Chi, Kwan-Hwa
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2018
Onderwerpen:
Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805523/
https://ncbi.nlm.nih.gov/pubmed/29467937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23855
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