Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells

Glioblastoma (GBM) cells are characterized by high phagocytosis, lipogenesis, exocytosis activities, low autophagy capacity and high lysosomal demand are necessary for survival and invasion. The lysosome stands at the cross roads of lipid biosynthesis, transporting, sorting between exogenous and end...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Hsu, Sanford P.C., Kuo, John S., Chiang, Hsin-Chien, Wang, Hsin-Ell, Wang, Yu-Shan, Huang, Cheng-Chung, Huang, Yi-Chun, Chi, Mau-Shin, Mehta, Minesh P., Chi, Kwan-Hwa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805523/
https://ncbi.nlm.nih.gov/pubmed/29467937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23855
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