Rapamycin and hydroxychloroquine combination alters macrophage polarization and sensitizes glioblastoma to immune checkpoint inhibitors

INTRODUCTION: The failure of immune checkpoint inhibitor (ICPi) on glioblastoma (GBM) treatment underscores the need for improving therapeutic strategy. We aimed to change tumor associated macrophage (TAM) from M2 type (anti-inflammatory) to M1 (pro-inflammatory) type to increase the therapeutic res...

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Dettagli Bibliografici
Pubblicato in:J Neurooncol
Autori principali: Hsu, Sanford P. C., Chen, Yi-Ching, Chiang, Hsin-Chien, Huang, Yi-Chun, Huang, Cheng-Chung, Wang, Hsin-Ell, Wang, Yu-Shang, Chi, Kwan-Hwa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2020
Soggetti:
Laboratory Investigation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000510/
https://ncbi.nlm.nih.gov/pubmed/32020472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-019-03360-3
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