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MACROPHAGE POLARIZATION CONTRIBUTES TO GLIOBLASTOMA ERADICATION BY COMBINATION IMMUNOVIROTHERAPY AND IMMUNE CHECKPOINT BLOCKADE
Glioblastoma is an immunosuppressive, fatal brain cancer that contains glioblastoma stem-like cells (GSCs). Oncolytic herpes simplex virus (oHSV) selectively replicates in cancer cells, while inducing anti-tumor immunity. OHSV G47Δ expressing murine IL-12 (G47Δ-mIL12), antibodies to immune checkpoin...
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| Publicado no: | Cancer Cell |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5568814/ https://ncbi.nlm.nih.gov/pubmed/28810147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.07.006 |
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