MACROPHAGE POLARIZATION CONTRIBUTES TO GLIOBLASTOMA ERADICATION BY COMBINATION IMMUNOVIROTHERAPY AND IMMUNE CHECKPOINT BLOCKADE

Glioblastoma is an immunosuppressive, fatal brain cancer that contains glioblastoma stem-like cells (GSCs). Oncolytic herpes simplex virus (oHSV) selectively replicates in cancer cells, while inducing anti-tumor immunity. OHSV G47Δ expressing murine IL-12 (G47Δ-mIL12), antibodies to immune checkpoin...

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Udgivet i:Cancer Cell
Main Authors: Saha, Dipongkor, Martuza, Robert L., Rabkin, Samuel D.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568814/
https://ncbi.nlm.nih.gov/pubmed/28810147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.07.006
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