Intracellular Permeation of Na(+) in an Active State G-Protein Coupled Receptor

Playing a central role in cell signaling, GPCRs have evolved into the largest superfamily of membrane proteins and form the majority of drug targets in humans. How extracellular agonist binding triggers the activation of GPCRs and associated intracellular effector proteins remains, however, poorly u...

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Bibliographic Details
Published in:Structure
Main Authors: Vickery, Owen N., Carvalheda, Catarina A., Zaidi, Saheem A., Pisliakov, Andrei V., Katritch, Vsevolod, Zachariae, Ulrich
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805466/
https://ncbi.nlm.nih.gov/pubmed/29249607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.11.013
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