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Structural Mechanisms of Voltage Sensing in G Protein-Coupled Receptors

G-protein-coupled receptors (GPCRs) form the largest superfamily of membrane proteins and one-third of all drug targets in humans. A number of recent studies have reported evidence for substantial voltage regulation of GPCRs. However, the structural basis of GPCR voltage sensing has remained enigmat...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Vickery, Owen N., Machtens, Jan-Philipp, Tamburrino, Giulia, Seeliger, Daniel, Zachariae, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906246/
https://ncbi.nlm.nih.gov/pubmed/27210286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.04.007
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