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Membrane potentials regulating GPCRs: insights from experiments and molecular dynamics simulations

G-protein coupled receptors (GPCRs) form the largest class of membrane proteins in humans and the targets of most present drugs. Membrane potential is one of the defining characteristics of living cells. Recent work has shown that the membrane voltage, and changes thereof, modulates signal transduct...

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Detalhes bibliográficos
Publicado no:Curr Opin Pharmacol
Main Authors: Vickery, Owen N, Machtens, Jan-Philipp, Zachariae, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080454/
https://ncbi.nlm.nih.gov/pubmed/27474871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coph.2016.06.011
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