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Intracellular Permeation of Na(+) in an Active State G-Protein Coupled Receptor

Playing a central role in cell signaling, GPCRs have evolved into the largest superfamily of membrane proteins and form the majority of drug targets in humans. How extracellular agonist binding triggers the activation of GPCRs and associated intracellular effector proteins remains, however, poorly u...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Structure
Hauptverfasser: Vickery, Owen N., Carvalheda, Catarina A., Zaidi, Saheem A., Pisliakov, Andrei V., Katritch, Vsevolod, Zachariae, Ulrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805466/
https://ncbi.nlm.nih.gov/pubmed/29249607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.11.013
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