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Structural Mechanism of Voltage-Dependent Gating in an Isolated Voltage-Sensing Domain
The transduction of transmembrane electric fields into protein motion plays an essential role in the generation and propagation of cellular signals. Voltage-sensing domains (VSD) carry out these functions through reorientations of S4 helix with discrete gating charges. Here, crystal structures of th...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4116111/ https://ncbi.nlm.nih.gov/pubmed/24487958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2768 |
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