Structural Mechanism of Voltage-Dependent Gating in an Isolated Voltage-Sensing Domain

The transduction of transmembrane electric fields into protein motion plays an essential role in the generation and propagation of cellular signals. Voltage-sensing domains (VSD) carry out these functions through reorientations of S4 helix with discrete gating charges. Here, crystal structures of th...

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Hlavní autoři: Li, Qufei, Wanderling, Sherry, Paduch, Marcin, Medovoy, David, Singharoy, Abhishek, McGreevy, Ryan, Villalba-Galea, Carlos, Hulse, Raymond E., Roux, Benoit, Schulten, Klaus, Kossiakoff, Anthony, Perozo, Eduardo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116111/
https://ncbi.nlm.nih.gov/pubmed/24487958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2768
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