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Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface
The ecto-5’-nucleotidase CD73 plays an important role in the production of immune-suppressive adenosine in tumor micro-environment, and has become a validated drug target in oncology. Indeed, the anticancer immune response involves extracellular ATP to block cell proliferation through T-cell activat...
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| Publicado no: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5805337/ https://ncbi.nlm.nih.gov/pubmed/29377887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005943 |
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