Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface

The ecto-5’-nucleotidase CD73 plays an important role in the production of immune-suppressive adenosine in tumor micro-environment, and has become a validated drug target in oncology. Indeed, the anticancer immune response involves extracellular ATP to block cell proliferation through T-cell activat...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Principais autores: Rahimova, Rahila, Fontanel, Simon, Lionne, Corinne, Jordheim, Lars Peter, Peyrottes, Suzanne, Chaloin, Laurent
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5805337/
https://ncbi.nlm.nih.gov/pubmed/29377887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005943
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