Direct Observation of Insulin Association Dynamics with Time-Resolved X-ray Scattering

Biological functions frequently require protein–protein interactions that involve secondary and tertiary structural perturbation. Here we study protein–protein dissociation and reassociation dynamics in insulin, a model system for protein oligomerization. Insulin dimer dissociation into monomers was...

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Udgivet i:J Phys Chem Lett
Main Authors: Rimmerman, Dolev, Leshchev, Denis, Hsu, Darren J., Hong, Jiyun, Kosheleva, Irina, Chen, Lin X.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5804350/
https://ncbi.nlm.nih.gov/pubmed/28853898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpclett.7b01720
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