Unfolding bovine α-lactalbumin with T-jump: Characterizing disordered intermediates via time-resolved x-ray solution scattering and molecular dynamics simulations

The protein folding process often proceeds through partially folded transient states. Therefore, a structural understanding of these disordered states is crucial for developing mechanistic models of the folding process. Characterization of unfolded states remains challenging due to their disordered...

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Bibliographic Details
Published in:J Chem Phys
Main Authors: Hsu, Darren J., Leshchev, Denis, Kosheleva, Irina, Kohlstedt, Kevin L., Chen, Lin X.
Format: Artigo
Language:Inglês
Published: AIP Publishing LLC 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943248/
https://ncbi.nlm.nih.gov/pubmed/33722011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/5.0039194
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