AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle

Phosphatidylcholines (PC) and S-adenosylmethionine (SAM) are critical determinants of hepatic lipid levels, but how their levels are regulated is unclear. Here, we show that Pemt and Gnmt, key one-carbon cycle genes regulating PC/SAM levels, are downregulated after feeding, leading to decreased PC a...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Kim, Young-Chae, Seok, Sunmi, Byun, Sangwon, Kong, Bo, Zhang, Yang, Guo, Grace, Xie, Wen, Ma, Jian, Kemper, Byron, Kemper, Jongsook Kim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803255/
https://ncbi.nlm.nih.gov/pubmed/29416063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03060-y
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