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Induced structural disorder as a molecular mechanism for enzyme dysfunction in phosphoglucomutase 1 deficiency

Human phosphoglucomutase 1 (PGM1) plays a central role in cellular glucose homeostasis, mediating the switch between glycolysis and gluconeogenesis through the conversion of glucose 1-phosphate and glucose 6-phosphate. Recent clinical studies have identified mutations in this enzyme as the cause of...

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Vydáno v:J Mol Biol
Hlavní autoři: Stiers, Kyle M., Kain, Bailee N., Graham, Abigail C., Beamer, Lesa J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802404/
https://ncbi.nlm.nih.gov/pubmed/26972339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.02.032
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