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Induced structural disorder as a molecular mechanism for enzyme dysfunction in phosphoglucomutase 1 deficiency
Human phosphoglucomutase 1 (PGM1) plays a central role in cellular glucose homeostasis, mediating the switch between glycolysis and gluconeogenesis through the conversion of glucose 1-phosphate and glucose 6-phosphate. Recent clinical studies have identified mutations in this enzyme as the cause of...
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| Veröffentlicht in: | J Mol Biol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5802404/ https://ncbi.nlm.nih.gov/pubmed/26972339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.02.032 |
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