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Sequence-structure relationships, expression profiles, and disease-associated mutations in the paralogs of phosphoglucomutase 1

The key metabolic enzyme phosphoglucomutase 1 (PGM1) controls glucose homeostasis in most human cells. Four proteins related to PGM1, known as PGM2, PGM2L1, PGM3 and PGM5, and referred to herein as paralogs, are encoded in the human genome. Although all members of the same enzyme superfamily, these...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Muenks, Andrew G., Stiers, Kyle M., Beamer, Lesa J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570346/
https://ncbi.nlm.nih.gov/pubmed/28837627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0183563
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