Massively parallel de novo protein design for targeted therapeutics

De novo protein design holds promise for creating small stable proteins with shapes customized to bind therapeutic targets. We describe a massively parallel approach for designing, manufacturing and screening mini-protein binders, integrating large-scale computational design, oligonucleotide synthes...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Chevalier, Aaron, Silva, Daniel-Adriano, Rocklin, Gabriel J., Hicks, Derrick R., Vergara, Renan, Murapa, Patience, Bernard, Steffen M., Zhang, Lu, Lam, Kwok-Ho, Yao, Guorui, Bahl, Christopher D., Miyashita, Shin-Ichiro, Goreshnik, Inna, Fuller, James T., Koday, Merika T., Jenkins, Cody M., Colvin, Tom, Carter, Lauren, Bohn, Alan, Bryan, Cassie M., Fernández-Velasco, D. Alejandro, Stewart, Lance, Dong, Min, Huang, Xuhui, Jin, Rongsheng, Wilson, Ian A., Fuller, Deborah H., Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802399/
https://ncbi.nlm.nih.gov/pubmed/28953867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23912
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