A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response

Broadly neutralizing antibodies targeting a highly conserved region in the hemagglutinin (HA) stem protect against influenza infection. Here, we investigate the protective efficacy of a protein (HB36.6) computationally designed to bind with high affinity to the same region in the HA stem. We show th...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Principais autores: Koday, Merika Treants, Nelson, Jorgen, Chevalier, Aaron, Koday, Michael, Kalinoski, Hannah, Stewart, Lance, Carter, Lauren, Nieusma, Travis, Lee, Peter S., Ward, Andrew B., Wilson, Ian A., Dagley, Ashley, Smee, Donald F., Baker, David, Fuller, Deborah Heydenburg
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742065/
https://ncbi.nlm.nih.gov/pubmed/26845438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005409
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