A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response

Broadly neutralizing antibodies targeting a highly conserved region in the hemagglutinin (HA) stem protect against influenza infection. Here, we investigate the protective efficacy of a protein (HB36.6) computationally designed to bind with high affinity to the same region in the HA stem. We show th...

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Publicat a:PLoS Pathog
Autors principals: Koday, Merika Treants, Nelson, Jorgen, Chevalier, Aaron, Koday, Michael, Kalinoski, Hannah, Stewart, Lance, Carter, Lauren, Nieusma, Travis, Lee, Peter S., Ward, Andrew B., Wilson, Ian A., Dagley, Ashley, Smee, Donald F., Baker, David, Fuller, Deborah Heydenburg
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742065/
https://ncbi.nlm.nih.gov/pubmed/26845438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005409
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