Sustained AAV9-mediated expression of a non-self protein in the CNS of non-human primates after immunomodulation

A critical issue in transgene delivery studies is immune reactivity to the transgene- encoded protein and its impact on sustained gene expression. Here, we test the hypothesis that immunomodulation by rapamycin can decrease immune reactivity after intrathecal AAV9 delivery of a transgene (GFP) in no...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Ramsingh, Arlene I., Gray, Steven J., Reilly, Andrew, Koday, Michael, Bratt, Debbie, Koday, Merika Treants, Murnane, Robert, Smedley, Jeremy, Hu, Yuhui, Messer, Anne, Fuller, Deborah Heydenburg
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2018
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991358/
https://ncbi.nlm.nih.gov/pubmed/29874260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198154
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