Extensive Transduction and Enhanced Spread of a Modified AAV2 Capsid in the Non-human Primate CNS

The present study was designed to characterize transduction of non-human primate brain and spinal cord with a modified adeno-associated virus serotype 2, incapable of binding to the heparan sulfate proteoglycan receptor, referred to as AAV2-HBKO. AAV2-HBKO was infused into the thalamus, intracerebro...

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Опубликовано в: :Mol Ther
Главные авторы: Naidoo, Jerusha, Stanek, Lisa M., Ohno, Kousaku, Trewman, Savanah, Samaranch, Lluis, Hadaczek, Piotr, O’Riordan, Catherine, Sullivan, Jennifer, San Sebastian, Waldy, Bringas, John R., Snieckus, Christopher, Mahmoodi, Amin, Mahmoodi, Amir, Forsayeth, John, Bankiewicz, Krystof S., Shihabuddin, Lamya S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Gene & Cell Therapy 2018
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6171051/
https://ncbi.nlm.nih.gov/pubmed/30057240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.07.008
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