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Mechanistic view of hnRNPA2 low complexity domain structure, interactions, and phase separation altered by disease mutation and arginine methylation
nRNPA2, a component of RNA processing membraneless organelles, forms inclusions when mutated in a syndrome characterized by degeneration of neurons (bearing features of ALS and frontotemporal dementia), muscle, and bone. Here we provide a unified structural view of hnRNPA2 self-assembly, aggregation...
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| Publicat a: | Mol Cell |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5801700/ https://ncbi.nlm.nih.gov/pubmed/29358076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.12.022 |
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