Mechanistic view of hnRNPA2 low complexity domain structure, interactions, and phase separation altered by disease mutation and arginine methylation

nRNPA2, a component of RNA processing membraneless organelles, forms inclusions when mutated in a syndrome characterized by degeneration of neurons (bearing features of ALS and frontotemporal dementia), muscle, and bone. Here we provide a unified structural view of hnRNPA2 self-assembly, aggregation...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Ryan, Veronica H., Dignon, Gregory L., Zerze, Gul H., Chabata, Charlene V., Silva, Rute, Conicella, Alexander E., Amaya, Joshua, Burke, Kathleen A., Mittal, Jeetain, Fawzi, Nicolas L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5801700/
https://ncbi.nlm.nih.gov/pubmed/29358076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.12.022
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