The Stress Kinase JNK Regulates Gap Junction Cx43 Gene Expression and Promotes Atrial Fibrillation in the Aged Heart

BACKGROUND: The stress kinase c-jun N-terminal kinase (JNK) is critical in the pathogenesis of cardiac diseases associated with an increased incidence of atrial fibrillation (AF), the most common arrhythmia in the elderly. We recently discovered that JNK activation is linked to the loss of gap junct...

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Gepubliceerd in:J Mol Cell Cardiol
Hoofdauteurs: Yan, Jiajie, Thomson, Justin K, Zhao, Weiwei, Wu, Xiaomin, Gao, Xianlong, DeMarco, Dominic, Kong, Wei, Tong, Min, Sun, Jun, Bakhos, Mamdouh, Fast, Vladimir G., Liang, Qingrong, Prabhu, Sumanth D, Ai, Xun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800987/
https://ncbi.nlm.nih.gov/pubmed/29146153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2017.11.006
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