The Stress Kinase JNK Regulates Gap Junction Cx43 Gene Expression and Promotes Atrial Fibrillation in the Aged Heart

BACKGROUND: The stress kinase c-jun N-terminal kinase (JNK) is critical in the pathogenesis of cardiac diseases associated with an increased incidence of atrial fibrillation (AF), the most common arrhythmia in the elderly. We recently discovered that JNK activation is linked to the loss of gap junct...

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Bibliografiske detaljer
Udgivet i:J Mol Cell Cardiol
Main Authors: Yan, Jiajie, Thomson, Justin K, Zhao, Weiwei, Wu, Xiaomin, Gao, Xianlong, DeMarco, Dominic, Kong, Wei, Tong, Min, Sun, Jun, Bakhos, Mamdouh, Fast, Vladimir G., Liang, Qingrong, Prabhu, Sumanth D, Ai, Xun
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800987/
https://ncbi.nlm.nih.gov/pubmed/29146153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2017.11.006
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