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Biophysical models of protein evolution: Understanding the patterns of evolutionary sequence divergence

For decades, rates of protein evolution have been interpreted in terms of the vague concept of “functional importance”. Slowly evolving proteins or sites within proteins were assumed to be more functionally important and thus subject to stronger selection pressure. More recently, biophysical models...

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Dettagli Bibliografici
Pubblicato in:Annu Rev Biophys
Autori principali: Echave, Julian, Wilke, Claus O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800964/
https://ncbi.nlm.nih.gov/pubmed/28301766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biophys-070816-033819
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