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Biophysical models of protein evolution: Understanding the patterns of evolutionary sequence divergence

For decades, rates of protein evolution have been interpreted in terms of the vague concept of “functional importance”. Slowly evolving proteins or sites within proteins were assumed to be more functionally important and thus subject to stronger selection pressure. More recently, biophysical models...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Annu Rev Biophys
Main Authors: Echave, Julian, Wilke, Claus O.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800964/
https://ncbi.nlm.nih.gov/pubmed/28301766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biophys-070816-033819
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