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Drug-drug interactions between Atorvastatin and Dronedarone mediated by monomeric CYP3A4

Heterotropic interactions between atorvastatin (ARVS) and dronedarone (DND) have been deciphered using global analysis of the results of binding and turnover experiments for pure drugs and their mixtures. The in vivo presence of atorvastatin lactone (ARVL) was explicitly taken into account by using...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Denisov, Ilia G., Baylon, Javier L., Grinkova, Yelena V., Tajkhorshid, Emad, Sligar, Stephen G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800941/
https://ncbi.nlm.nih.gov/pubmed/29200287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b01012
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