RGS4 Overexpression in Lung Attenuates Airway Hyperresponsiveness in Mice

A cardinal feature of asthma is airway hyperresponsiveness (AHR) to spasmogens, many of which activate G protein–coupled receptors (GPCRs) on airway smooth muscle (ASM) cells. Asthma subtypes associated with allergy are characterized by eosinophilic inflammation in the lung due to the type 2 immune...

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Vydáno v:Am J Respir Cell Mol Biol
Hlavní autoři: Madigan, Laura A., Wong, Gordon S., Gordon, Elizabeth M., Chen, Wei-Sheng, Balenga, Nariman, Koziol-White, Cynthia J., Panettieri, Reynold A., Levine, Stewart J., Druey, Kirk M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2018
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800898/
https://ncbi.nlm.nih.gov/pubmed/28853915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0109OC
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