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Dissociation of FK506-Binding Protein 12.6 kD from Ryanodine Receptor in Bronchial Smooth Muscle Cells in Airway Hyperresponsiveness in Asthma

Airway hyperresponsiveness (AHR) in asthma is predominantly caused by increased sensitivity of bronchial smooth muscle cells (BSMCs) to stimuli. The sarcoplasmic reticulum (SR)-Ca(2+) release channel, known as ryanodine receptor (RyR), mediates the contractive response of BSMCs to stimuli. FK506-bin...

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Bibliografiske detaljer
Udgivet i:Am J Respir Cell Mol Biol
Main Authors: Du, Ying, Zhao, Jianhong, Li, Xi, Jin, Si, Ma, Wan-Li, Mu, Qing, Xu, Shuxiang, Yang, Jie, Rao, Shanshan, Zhu, Liping, Xin, Jianbao, Cai, Peng-Cheng, Su, Yunchao, Ye, Hong
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800890/
https://ncbi.nlm.nih.gov/pubmed/24053175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0222OC
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