Dissociation of FK506-Binding Protein 12.6 kD from Ryanodine Receptor in Bronchial Smooth Muscle Cells in Airway Hyperresponsiveness in Asthma

Airway hyperresponsiveness (AHR) in asthma is predominantly caused by increased sensitivity of bronchial smooth muscle cells (BSMCs) to stimuli. The sarcoplasmic reticulum (SR)-Ca(2+) release channel, known as ryanodine receptor (RyR), mediates the contractive response of BSMCs to stimuli. FK506-bin...

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Detalles Bibliográficos
Publicado en:Am J Respir Cell Mol Biol
Autores principales: Du, Ying, Zhao, Jianhong, Li, Xi, Jin, Si, Ma, Wan-Li, Mu, Qing, Xu, Shuxiang, Yang, Jie, Rao, Shanshan, Zhu, Liping, Xin, Jianbao, Cai, Peng-Cheng, Su, Yunchao, Ye, Hong
Formato: Artigo
Lenguaje:Inglês
Publicado: American Thoracic Society 2014
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800890/
https://ncbi.nlm.nih.gov/pubmed/24053175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0222OC
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