Dissociation of FK506-Binding Protein 12.6 kD from Ryanodine Receptor in Bronchial Smooth Muscle Cells in Airway Hyperresponsiveness in Asthma

Airway hyperresponsiveness (AHR) in asthma is predominantly caused by increased sensitivity of bronchial smooth muscle cells (BSMCs) to stimuli. The sarcoplasmic reticulum (SR)-Ca(2+) release channel, known as ryanodine receptor (RyR), mediates the contractive response of BSMCs to stimuli. FK506-bin...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Du, Ying, Zhao, Jianhong, Li, Xi, Jin, Si, Ma, Wan-Li, Mu, Qing, Xu, Shuxiang, Yang, Jie, Rao, Shanshan, Zhu, Liping, Xin, Jianbao, Cai, Peng-Cheng, Su, Yunchao, Ye, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800890/
https://ncbi.nlm.nih.gov/pubmed/24053175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0222OC
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