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L1 retrotransposon antisense RNA within ASAR lncRNAs controls chromosome-wide replication timing

Mammalian cells replicate their chromosomes via a temporal replication program. The ASAR6 and ASAR15 genes were identified as loci that when disrupted result in delayed replication and condensation of entire human chromosomes. ASAR6 and ASAR15 are monoallelically expressed long noncoding RNAs that r...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Platt, Emily J., Smith, Leslie, Thayer, Mathew J.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800813/
https://ncbi.nlm.nih.gov/pubmed/29288153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201707082
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