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L1 retrotransposon antisense RNA within ASAR lncRNAs controls chromosome-wide replication timing

Mammalian cells replicate their chromosomes via a temporal replication program. The ASAR6 and ASAR15 genes were identified as loci that when disrupted result in delayed replication and condensation of entire human chromosomes. ASAR6 and ASAR15 are monoallelically expressed long noncoding RNAs that r...

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Bibliographische Detailangaben
Veröffentlicht in:J Cell Biol
Hauptverfasser: Platt, Emily J., Smith, Leslie, Thayer, Mathew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800813/
https://ncbi.nlm.nih.gov/pubmed/29288153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201707082
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