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STAT3 expression by myeloid cells is detrimental for the T- cell-mediated control of infection with Mycobacterium tuberculosis
STAT3 is a master regulator of the immune responses. Here we show that M. tuberculosis-infected stat3(fl/fl) lysm cre mice, defective for STAT3 in myeloid cells, contained lower bacterial load in lungs and spleens, reduced granuloma extension but higher levels of pulmonary neutrophils. STAT3-deficie...
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Publicado no: | PLoS Pathog |
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Main Authors: | , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5800682/ https://ncbi.nlm.nih.gov/pubmed/29338039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006809 |
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