Silencing Suppressor of Cytokine Signaling-1 (SOCS1) in Macrophages Improves Mycobacterium tuberculosis Control in an Interferon-γ (IFN-γ)-dependent Manner

Protection against infection with Mycobacterium tuberculosis demands IFN-γ. SOCS1 has been shown to inhibit responses to IFN-γ and might thereby play a central role in the outcome of infection. We found that M. tuberculosis is a highly efficient stimulator of SOCS1 expression in murine and human mac...

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Autores principales: Carow, Berit, qun Ye, Xiang, Gavier-Widén, Dolores, Bhuju, Sabin, Oehlmann, Wulf, Singh, Mahavir, Sköld, Markus, Ignatowicz, Lech, Yoshimura, Akihiko, Wigzell, Hans, Rottenberg, Martin E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143647/
https://ncbi.nlm.nih.gov/pubmed/21622562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.238287
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