STAT3 expression by myeloid cells is detrimental for the T- cell-mediated control of infection with Mycobacterium tuberculosis

STAT3 is a master regulator of the immune responses. Here we show that M. tuberculosis-infected stat3(fl/fl) lysm cre mice, defective for STAT3 in myeloid cells, contained lower bacterial load in lungs and spleens, reduced granuloma extension but higher levels of pulmonary neutrophils. STAT3-deficie...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Pathog
Egile Nagusiak: Gao, Yu, Basile, Juan Ignacio, Classon, Cajsa, Gavier-Widen, Dolores, Yoshimura, Akihiko, Carow, Berit, Rottenberg, Martin E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2018
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800682/
https://ncbi.nlm.nih.gov/pubmed/29338039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006809
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak