Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer

Constitutive activation of interferon signaling pathways has been reported in colorectal cancer (CRC), leading to a strong CD8(+) T cell response through stimulation of NLRC5 expression. Primed CD8(+) T cell expansion, however, may be negatively regulated by PD-L1 expression. Additionally, aberrant...

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Publicado en:PLoS One
Autores principales: Catalano, Calogerina, da Silva Filho, Miguel Inacio, Frank, Christoph, Jiraskova, Katerina, Vymetalkova, Veronika, Levy, Miroslav, Liska, Vaclav, Vycital, Ondrej, Naccarati, Alessio, Vodickova, Ludmila, Hemminki, Kari, Vodicka, Pavel, Weber, Alexander N. R., Försti, Asta
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800657/
https://ncbi.nlm.nih.gov/pubmed/29408916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192385
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