Investigation of single and synergic effects of NLRC5 and PD-L1 variants on the risk of colorectal cancer

Constitutive activation of interferon signaling pathways has been reported in colorectal cancer (CRC), leading to a strong CD8(+) T cell response through stimulation of NLRC5 expression. Primed CD8(+) T cell expansion, however, may be negatively regulated by PD-L1 expression. Additionally, aberrant...

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Udgivet i:PLoS One
Main Authors: Catalano, Calogerina, da Silva Filho, Miguel Inacio, Frank, Christoph, Jiraskova, Katerina, Vymetalkova, Veronika, Levy, Miroslav, Liska, Vaclav, Vycital, Ondrej, Naccarati, Alessio, Vodickova, Ludmila, Hemminki, Kari, Vodicka, Pavel, Weber, Alexander N. R., Försti, Asta
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800657/
https://ncbi.nlm.nih.gov/pubmed/29408916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192385
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