Triptolide induces Sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response

Triptolide (TP), an oxygenated diterpene, has a variety of beneficial pharmacodynamic activities but its clinical applications are restricted due to severe testicular injury. This study aimed to delineate the molecular mechanisms of TP-induced testicular injury in vitro and in vivo. TP (5–50000 nmol...

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Wang, Yu, Guo, Su-han, Shang, Xue-jun, Yu, Li-sha, Zhu, Jian-wei, Zhao, Ang, Zhou, Yan-fen, An, Guo-hua, Zhang, Qi, Ma, Bo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2018
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800476/
https://ncbi.nlm.nih.gov/pubmed/28905938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.95
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