Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos

Aconitine (AC), one of the bioactive diterpenoid alkaloids extracted from Aconitum plants, is widely used in traditional herbal medicine to treat various diseases. Emerging evidence indicates that AC has attracted great interest for its wide cardiotoxicity and neurotoxicity. However, the toxic effec...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Xia, Qing, Gao, Shuo, Rapael Gnanamuthu, Samuel Rajendran, Zhuang, Kaiyan, Song, Zhenzhen, Zhang, Yun, Wang, Xue, Tu, Pengfei, Li, Jianheng, Liu, Kechun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097150/
https://ncbi.nlm.nih.gov/pubmed/33967776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.642480
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