Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes

Unraveling the mechanism of action and molecular target of small molecules remains a major challenge in drug discovery. While many cancer drugs target genetic vulnerabilities, loss-of-function screens fail to identify essential genes in drug mechanism of action. Here, we report CRISPRres, a CRISPR-C...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Neggers, Jasper Edgar, Kwanten, Bert, Dierckx, Tim, Noguchi, Hiroki, Voet, Arnout, Bral, Lotte, Minner, Kristien, Massant, Bob, Kint, Nicolas, Delforge, Michel, Vercruysse, Thomas, Baloglu, Erkan, Senapedis, William, Jacquemyn, Maarten, Daelemans, Dirk
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799254/
https://ncbi.nlm.nih.gov/pubmed/29402884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02349-8
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