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Computational modelling of pathogenic protein spread in neurodegenerative diseases

Pathogenic protein accumulation and spread are fundamental principles of neurodegenerative diseases and ultimately account for the atrophy patterns that distinguish these diseases clinically. However, the biological mechanisms that link pathogenic proteins to specific neural network damage patterns...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Georgiadis, Konstantinos, Wray, Selina, Ourselin, Sébastien, Warren, Jason D., Modat, Marc
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798854/
https://ncbi.nlm.nih.gov/pubmed/29401516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0192518
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