Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells

Bcl-2 family proteins regulate apoptosis, and aberrant interactions of overexpressed antiapoptotic family members such as Mcl-1 promote cell transformation, cancer survival, and resistance to chemotherapy. Discovering potent and selective Mcl-1 inhibitors that can relieve apoptotic blockades is thus...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rezaei Araghi, Raheleh, Bird, Gregory H., Ryan, Jeremy A., Jenson, Justin M., Godes, Marina, Pritz, Jonathan R., Grant, Robert A., Letai, Anthony, Walensky, Loren D., Keating, Amy E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798337/
https://ncbi.nlm.nih.gov/pubmed/29339518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712952115
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