Tertiary structural motif sequence statistics enable facile prediction and design of peptides that bind anti-apoptotic Bfl-1 and Mcl-1

per Frappier, Vincent, Jenson, Justin M., Zhou, Jianfu, Grigoryan, Gevorg, Keating, Amy E.
Publicat a Structure (2019)

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

per Jenson, Justin M, Ryan, Jeremy A, Grant, Robert A, Letai, Anthony, Keating, Amy E
Publicat a eLife (2017)

Peptide design by optimization on a data-parameterized protein interaction landscape

per Jenson, Justin M., Xue, Vincent, Stretz, Lindsey, Mandal, Tirtha, Reich, Lothar “Luther”, Keating, Amy E.
Publicat a Proc Natl Acad Sci U S A (2018)

Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells

per Rezaei Araghi, Raheleh, Bird, Gregory H., Ryan, Jeremy A., Jenson, Justin M., Godes, Marina, Pritz, Jonathan R., Grant, Robert A., Letai, Anthony, Walensky, Loren D., Keating, Amy E.
Publicat a Proc Natl Acad Sci U S A (2018)