A membrane-associated, fluorogenic reporter for mammalian phospholipase C isozymes

A diverse group of cell-surface receptors, including many G protein-coupled receptors and receptor tyrosine kinases, activate phospholipase C (PLC) isozymes to hydrolyze phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol and 1,4,5-inositol trisphosphate. Consequently, PL...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Huang, Weigang, Wang, Xiaoyang, Endo-Streeter, Stuart, Barrett, Matthew, Waybright, Jarod, Wohlfeld, Christian, Hajicek, Nicole, Harden, T. Kendall, Sondek, John, Zhang, Qisheng
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Lipids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798302/
https://ncbi.nlm.nih.gov/pubmed/29263090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000926
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