Metabolic stress regulates ERK activity by controlling KSR‐RAF heterodimerization

Altered cell metabolism is a hallmark of cancer, and targeting specific metabolic nodes is considered an attractive strategy for cancer therapy. In this study, we evaluate the effects of metabolic stressors on the deregulated ERK pathway in melanoma cells bearing activating mutations of the NRAS or...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Verlande, Amandine, Krafčíková, Michaela, Potěšil, David, Trantírek, Lukáš, Zdráhal, Zbyněk, Elkalaf, Moustafa, Trnka, Jan, Souček, Karel, Rauch, Nora, Rauch, Jens, Kolch, Walter, Uldrijan, Stjepan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797961/
https://ncbi.nlm.nih.gov/pubmed/29263201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201744524
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