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Development and Implementation of an HTS-Compatible Assay for the Discovery of Selective Small-Molecule Ligands for Pre-microRNAs

microRNAs (miRNAs) are small gene regulatory RNAs, and their expression has been found to be dysregulated in a number of human diseases. To facilitate the discovery of small molecules capable of selectively modulating the activity of a specific miRNA, we have utilized new high-throughput screening t...

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Bibliografski detalji
Izdano u:SLAS Discov
Glavni autori: Lorenz, Daniel A., Vander Roest, Steve, Larsen, Martha J., Garner, Amanda L.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797708/
https://ncbi.nlm.nih.gov/pubmed/28686847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555217717944
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