Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL

The Janus kinase 3 (JAK3) tyrosine kinase is mutated in 10% to 16% of T-cell acute lymphoblastic leukemia (T-ALL) cases. JAK3 mutants induce constitutive JAK/STAT signaling and cause leukemia when expressed in the bone marrow cells of mice. Surprisingly, we observed that one third of JAK3-mutant T-A...

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Bibliografiska uppgifter
I publikationen:Blood
Huvudupphovsmän: Degryse, Sandrine, Bornschein, Simon, de Bock, Charles E., Leroy, Emilie, Vanden Bempt, Marlies, Demeyer, Sofie, Jacobs, Kris, Geerdens, Ellen, Gielen, Olga, Soulier, Jean, Harrison, Christine J., Constantinescu, Stefan N., Cools, Jan
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2018
Ämnen:
Lymphoid Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796683/
https://ncbi.nlm.nih.gov/pubmed/29187379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-07-797597
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