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The role of spatial organization of Ca(2+) release sites in the generation of arrhythmogenic diastolic Ca(2+) release in myocytes from failing hearts

In heart failure (HF), dysregulated cardiac ryanodine receptors (RyR2) contribute to the generation of diastolic Ca(2+) waves (DCWs), thereby predisposing adrenergically stressed failing hearts to life-threatening arrhythmias. However, the specific cellular, subcellular, and molecular defects that a...

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Bibliografiska uppgifter
I publikationen:Basic Res Cardiol
Huvudupphovsmän: Belevych, Andriy E., Ho, Hsiang-Ting, Bonilla, Ingrid M., Terentyeva, Radmila, Schober, Karsten E., Terentyev, Dmitry, Carnes, Cynthia A., Györke, Sándor
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5796415/
https://ncbi.nlm.nih.gov/pubmed/28612155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-017-0633-2
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